Sandler M, Ruthven C R, Goodwin B L, Coppen A
Clin Chim Acta. 1979 Apr 2;93(1):169-71. doi: 10.1016/0009-8981(79)90261-4.
Cerebrospinal fluid free phenylacetic acid concentration in a series of depressive patients was significantly lower than values in control subjects. This acid derives from phenylethylamine and the findings may reflect a decrease in its brain formation. Such a deficit may be related to other recent observations of a decrease in urinary output of the major metabolites of the "trace amines", octopamine and tyramine: phenylethylamine is thought to be the precursor of these "trace amines".
一系列抑郁症患者脑脊液中游离苯乙酸浓度显著低于对照组。这种酸源自苯乙胺，这些发现可能反映出其在大脑中的生成减少。这样一种不足可能与近期其他关于“痕量胺”（章鱼胺和酪胺）主要代谢产物尿量减少的观察结果有关：苯乙胺被认为是这些“痕量胺”的前体。
