Kent R B, Lyerly R T
Department of Surgery, Norwood Clinic, Birmingham, AL 35234.
South Med J. 1994 Feb;87(2):278-81. doi: 10.1097/00007611-199402000-00029.
Systemic calciphylaxis is a rare, poorly understood syndrome of progressive ischemic necrosis, usually associated with hyperparathyroidism. The combination of hyperparathyroidism, usually secondary or tertiary, and chronic renal failure seems to produce a particular biochemical environment conducive to the development of an unusual progressive form of ischemia. Early recognition and diagnosis, appropriate therapy including wound care, and expeditious parathyroidectomy often will halt the progression of the disease, minimize limb loss, and prevent subsequent sepsis and death.
系统性钙化防御是一种罕见的、了解甚少的进行性缺血性坏死综合征，通常与甲状旁腺功能亢进有关。甲状旁腺功能亢进（通常为继发性或三发性）与慢性肾衰竭的结合似乎产生了一种特殊的生化环境，有利于一种不寻常的进行性缺血形式的发展。早期识别和诊断、包括伤口护理在内的适当治疗以及迅速进行甲状旁腺切除术通常会阻止疾病进展，将肢体丧失降至最低，并预防随后的败血症和死亡。
