钙过敏症
Calciphylaxis.
作者信息
Mathur R V, Shortland J R, el-Nahas A M
机构信息
Northern General Hospital, Sheffield, UK.
出版信息
Postgrad Med J. 2001 Sep;77(911):557-61. doi: 10.1136/pmj.77.911.557.
Abstract
The phenomenon of calciphylaxis is rare, but potentially fatal. It has been recognised for a long time in patients with chronic renal failure with secondary hyperparathyroidism. Disturbed calcium and phosphate metabolism can result in painful necrosis of skin, subcutaneous tissue and acral gangrene. Appearance of the lesions is distinctive but the pathogenesis remains uncertain. The beneficial effects of parathyroidectomy are controversial. However, correction of hyperphosphataemia or occasionally hypercalcaemia is imperative. Fulminant sepsis as a consequence of secondary infection of necrotic and gangrenous tissue is a frequent cause of patient morbidity and mortality.
摘要
钙过敏现象罕见，但可能致命。长期以来，它在患有继发性甲状旁腺功能亢进的慢性肾衰竭患者中已得到认识。钙磷代谢紊乱可导致皮肤、皮下组织疼痛性坏死及肢端坏疽。病变外观独特，但发病机制仍不确定。甲状旁腺切除术的有益效果存在争议。然而，纠正高磷血症或偶尔的高钙血症势在必行。坏死和坏疽组织继发感染导致的暴发性脓毒症是患者发病和死亡的常见原因。
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本文引用的文献
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Hyperphosphatemia in end-stage renal disease patients: pathophysiological consequences.终末期肾病患者的高磷血症：病理生理后果。
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Calciphylaxis precipitated by ultraviolet light in a patient with end-stage renal disease secondary to systemic lupus erythematosus.紫外线诱发的钙化防御见于一名继发于系统性红斑狼疮的终末期肾病患者。
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