Hoffmann R, Schimmer R C, Largiadèr F
Department of Surgery, University Hospital of Zurich, Switzerland.
Thromb Haemost. 1993 Oct 18;70(4):712-6.
The aim of this experimental study was to determine whether deep vein thrombosis (DVT) in animals occurs after osteosynthesis of the femur, and whether a postoperative drop in air pressure increases the frequency of DVT. Thus, osteosynthesis of the femur was performed in 10 New Zealand rabbits. Postoperatively a drop in air pressure of 300 hPA was induced. After 40 h in the pressure cabin ascending phlebography was performed (Group A). In a control-group of 10 other rabbits surgery was performed without postoperative drop in air pressure (Group B) while in a second control only the drop in air pressure was induced without surgery (Group C). The phlebographic studies showed DVT in 4 out of 10 rabbits in group A. In group B there was no demonstrable DVT while in group C one case of DVT was seen. The difference between group A and group B and C is statistically significant. In conclusion, a rapid drop in air pressure seems to have significant impact on the pathogenesis of DVT in rabbits after osteosynthesis of the femur.
本实验研究的目的是确定在兔股骨进行骨接合术后是否会发生深静脉血栓形成（DVT），以及术后气压下降是否会增加DVT的发生率。因此，对10只新西兰兔进行了股骨骨接合术。术后诱导气压下降300百帕。在压力舱内40小时后进行上行静脉造影（A组）。在另一组10只兔的对照组中，手术时未进行术后气压下降（B组），而在第二个对照组中，仅诱导气压下降而未进行手术（C组）。静脉造影研究显示，A组10只兔中有4只出现DVT。B组未发现明显的DVT，而C组有1例DVT。A组与B组和C组之间的差异具有统计学意义。总之，气压的快速下降似乎对兔股骨骨接合术后DVT的发病机制有显著影响。
