Hans P, Brichant J F, Bonhomme V, Triffaux M
University Department of Anesthesiology and Intensive Care, CHR de la Citadelle, Liège.
Acta Anaesthesiol Belg. 1993;44(4):129-33.
The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients scheduled for lumbar disc surgery were randomly allocated to two groups. They were given either propacetamol 2 g or saline every 6 hours, starting at the end of procedure for a 24 hours period. The pain intensity (VAS) was not significantly different between the two groups except 3 and 4 hours after surgery, where it was higher in the paracetamol group. The cumulative narcotic consumption (piritramide on request) was higher in the placebo group from 6 hours till 9 hours after surgery but not significantly different after 24 hours. Piritramide administration decreased VAS score significantly in both groups while propacetamol reduced it in a significant way only when given from 12 hours after surgery.
在一项随机安慰剂对照研究中，评估了静脉注射盐酸丙帕他莫对术后镇痛及肌肉注射阿片类药物用量的影响。40例计划行腰椎间盘手术的患者被随机分为两组。从手术结束开始，每6小时给他们服用2g丙帕他莫或生理盐水，持续24小时。两组之间的疼痛强度（视觉模拟评分法）无显著差异，除了术后3小时和4小时，此时对乙酰氨基酚组的疼痛强度更高。安慰剂组术后6小时至9小时的累积麻醉药物用量（按需使用匹利卡明）更高，但24小时后无显著差异。两组中匹利卡明的使用均显著降低了视觉模拟评分法得分，而丙帕他莫仅在术后12小时开始给药时才显著降低该得分。
