Hutchinson M, Stack J, Buckley P
Department of Neurology, St. Vincent's Hospital, Dublin, Ireland.
Acta Neurol Scand. 1993 Dec;88(6):388-93. doi: 10.1111/j.1600-0404.1993.tb05365.x.
The frequent association of affective disorder and multiple sclerosis raises important aetiological and clinical considerations. Reported here are seven patients who presented with symptoms of multiple sclerosis and who had a preceding history of bipolar affective disorder. The hypothesis that bipolar illness may be the initial manifestation of multiple sclerosis is discussed with reference to relevant clinical and epidemiological research on the topic.
情感障碍与多发性硬化症的频繁关联引发了重要的病因学和临床思考。本文报告了7例出现多发性硬化症症状且既往有双相情感障碍病史的患者。结合该主题的相关临床和流行病学研究，对双相情感障碍可能是多发性硬化症的初始表现这一假说进行了讨论。
