Whitlock F A, Siskind M M
J Neurol Neurosurg Psychiatry. 1980 Oct;43(10):861-5. doi: 10.1136/jnnp.43.10.861.
Thirty patients suffering from multiple sclerosis have been compared with 30 patients suffering from other chronic neurological diseases. The degree of disability was similar in these two groups. The patients with multiple sclerosis had experienced more episodes of severe depression both before and after the onset of neurological symptoms. The possible reasons for these episodes are discussed and it is concluded that in some patients serious affective disorder may be a presenting or complicating feature of multiple sclerosis.
30名多发性硬化症患者与30名患有其他慢性神经疾病的患者进行了比较。两组患者的残疾程度相似。多发性硬化症患者在神经症状出现之前和之后都经历了更多次严重抑郁发作。文中讨论了这些发作的可能原因，并得出结论，在一些患者中，严重情感障碍可能是多发性硬化症的一个首发或并发特征。
