Stokes A F, Belger A, Banich M T, Bernadine E
University of Illinois, Institute of Aviation, Savoy.
Aviat Space Environ Med. 1994 Jan;65(1):7-15.
Acute dosing studies of aspartame, known commercially as "NutraSweet," have failed to demonstrate any neuropsychological changes that would imply performance decrements in flight operations. Such studies may be criticized on the grounds that the administration of a single, if large, dose of aspartame is not ecologically valid. Accordingly, a double-blind chronic dosing study of aspartame was conducted using ethanol (at 0.1% BAL) as the positive control. No detectable cognitive performance decrements were associated with the aspartame condition. However, the alcohol results exhibited a pattern of asymmetric lateral brain impairment that closely resembles that observed in studies of depressive patients. These results have operational implications as well as theoretical importance.
阿斯巴甜（商品名为“纽甜”）的急性给药研究未能证明有任何神经心理学变化，这些变化可能意味着飞行操作中的表现下降。此类研究可能会受到批评，理由是即使给予大剂量的阿斯巴甜单次给药也不符合生态学有效性。因此，以乙醇（血液酒精浓度为0.1%）作为阳性对照，进行了一项阿斯巴甜的双盲慢性给药研究。在阿斯巴甜给药条件下未发现可检测到的认知表现下降。然而，酒精的研究结果显示出一种大脑侧部不对称损伤模式，与抑郁症患者研究中观察到的模式非常相似。这些结果具有实际意义和理论重要性。
