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一种小鼠转化生长因子β I 型受体，其需要II型受体来结合配体。

A mouse TGF-beta type I receptor that requires type II receptor for ligand binding.

作者信息

Suzuki A, Shioda N, Maeda T, Tada M, Ueno N

机构信息

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

出版信息

Biochem Biophys Res Commun. 1994 Feb 15;198(3):1063-9. doi: 10.1006/bbrc.1994.1151.

DOI:10.1006/bbrc.1994.1151
PMID:8117262
Abstract

A cDNA for a serine/threonine kinase receptor was isolated from a mouse brain cDNA library. The receptor transiently expressed on COS cells bound TGF-beta 1 not by itself but only when TGF-beta type II receptor was coexpressed. The molecular mass of the ligand-receptor complex was estimated to be 75 kDa. The type II receptor-dependent binding and the molecular mass of the complex suggest that the receptor is a TGF-beta type I receptor.

摘要

从小鼠脑cDNA文库中分离出一种丝氨酸/苏氨酸激酶受体的cDNA。该受体在COS细胞上瞬时表达，其本身并不结合转化生长因子-β1（TGF-β1），只有在共表达TGF-βⅡ型受体时才能结合。配体-受体复合物的分子量估计为75 kDa。Ⅱ型受体依赖性结合及复合物的分子量表明该受体是TGF-βⅠ型受体。

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