Sastry S M, Sperduto R D, Waring G O, Remaley N A, Lynn M J, Blanco E, Miller D N
National Eye Institute, Biometry and Epidemiology Program, National Institutes of Health, Bethesda, MD 20892.
Refract Corneal Surg. 1993 Nov-Dec;9(6):459-64.
Recent reports have suggested that a secondary effect of radial keratotomy may be a reduction in intraocular pressure (IOP) levels.
In an effort to study the relationship of radial keratotomy to IOP, we compared the mean IOP from the baseline and follow-up visits during 1 year after surgery of operated versus nonoperated eyes of patients enrolled in the Prospective Evaluation of Radial Keratotomy (PERK) study. To investigate if radial keratotomy had more of an effect on eyes with higher baseline IOPs, the same analysis was performed on a subset (134 patients) who had a baseline IOP of 15 mm Hg or greater.
The average baseline IOP for both operated eyes and nonoperated eyes was 14.6 mm Hg. There was no significant difference in mean IOP between operated and nonoperated eyes across all time points (p = .18). Although mean IOP changed over time, it did not clinically differ in operated versus nonoperated eyes at any time point. These findings were similar in the analysis of eyes with higher baseline IOP (15 mm Hg or greater).
We conclude that the radial keratotomy performed in the PERK study had no effect on IOP within 1 year after surgery.
近期报告表明，放射状角膜切开术的一个次要效应可能是眼内压（IOP）水平降低。
为研究放射状角膜切开术与眼内压的关系，我们比较了参与放射状角膜切开术前瞻性评估（PERK）研究的患者手术眼与未手术眼术后1年内基线访视和随访访视时的平均眼内压。为调查放射状角膜切开术对基线眼内压较高的眼睛是否有更大影响，对基线眼内压为15毫米汞柱或更高的一个亚组（134例患者）进行了相同分析。
手术眼和未手术眼的平均基线眼内压均为14.6毫米汞柱。在所有时间点，手术眼和未手术眼的平均眼内压均无显著差异（p = 0.18）。尽管平均眼内压随时间变化，但在任何时间点，手术眼和未手术眼在临床上并无差异。在对基线眼内压较高（15毫米汞柱或更高）的眼睛进行的分析中，这些结果相似。
我们得出结论，PERK研究中进行的放射状角膜切开术在术后1年内对眼内压无影响。
