药物滥用和成瘾的动物模型：对科学、动物福利及社会的影响。
Animal models of substance abuse and addiction: implications for science, animal welfare, and society.
作者信息
Lynch Wendy J, Nicholson Katherine L, Dance Mario E, Morgan Richard W, Foley Patricia L
机构信息
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA.
出版信息
Comp Med. 2010 Jun;60(3):177-88.
Abstract
Substance abuse and addiction are well recognized public health concerns, with 2 NIH institutes (the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism) specifically targeting this societal problem. As such, this is an important area of research for which animal experiments play a critical role. This overview presents the importance of substance abuse and addiction in society; reviews the development and refinement of animal models that address crucial areas of biology, pathophysiology, clinical treatments, and drug screening for abuse liability; and discusses some of the unique veterinary, husbandry, and IACUC challenges associated with these models.
摘要
药物滥用和成瘾是公认的公共卫生问题，美国国立卫生研究院（NIH）的2个研究所（国家药物滥用研究所和国家酒精滥用与酒精中毒研究所）专门针对这一社会问题。因此，这是一个重要的研究领域，动物实验在其中发挥着关键作用。本综述介绍了药物滥用和成瘾在社会中的重要性；回顾了动物模型的发展和完善，这些模型涉及生物学、病理生理学、临床治疗以及药物滥用可能性筛查等关键领域；并讨论了与这些模型相关的一些独特的兽医、饲养管理和机构动物护理与使用委员会（IACUC）方面的挑战。
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