Maritz G S, Scott L, Thomas R A
Department of Physiological Sciences, University of the Western Cape, Bellville, South Africa.
Cell Biol Int. 1993 Dec;17(12):1085-9. doi: 10.1006/cbir.1993.1041.
The aim of the present study was to investigate the effect of maternal nicotine exposure (1 mg nicotine/kg body mass/day) on neonatal lung alveolar epithelial cells. Rats (Wistar descendants) were used. The data illustrate that maternal nicotine exposure during pregnancy and lactation resulted in alveolar fenestrations, blebbing and rupturing of the blood-air barrier. The type I pneumocyte appears to be more sensitive to the effect of nicotine than the type II pneumocytes.
本研究的目的是调查母体尼古丁暴露（1毫克尼古丁/千克体重/天）对新生鼠肺泡上皮细胞的影响。使用的是大鼠（Wistar后代）。数据表明，孕期和哺乳期母体尼古丁暴露会导致肺泡出现窗孔、形成泡状结构以及气血屏障破裂。I型肺泡上皮细胞似乎比II型肺泡上皮细胞对尼古丁的影响更敏感。
