母体尼古丁暴露对新生儿肺代谢的影响。维生素C的保护作用。

The influence of maternal nicotine exposure on neonatal lung metabolism. Protective effect of ascorbic acid.

作者信息

Maritz G S

机构信息

Department of Physiological Sciences, University of the Western Cape, Bellville, South Africa.

出版信息

Cell Biol Int. 1993 Jun;17(6):579-85. doi: 10.1006/cbir.1993.1102.

DOI:10.1006/cbir.1993.1102

PMID:8348117

Abstract

The aim of the present study was to establish whether ascorbic acid supplementation (1 mg/kg/body mass/day) during pregnancy and lactation will prevent the effect of maternal nicotine exposure (1 mg/kg/body weight/day) on neonatal lung carbohydrate, DNA and protein metabolism. The data show that the adult lung ascorbic acid content was reduced by 76% after exposure to nicotine. In contrast, maternal nicotine exposure during pregnancy and lactation has no effect on neonatal lung ascorbic acid content. However, ascorbic acid supplementation during pregnancy and lactation prevented the adverse effects of maternal nicotine exposure on neonatal lung carbohydrate, DNA and protein metabolism.

摘要

本研究的目的是确定在怀孕和哺乳期间补充抗坏血酸（1毫克/千克体重/天）是否能预防母体尼古丁暴露（1毫克/千克体重/天）对新生儿肺碳水化合物、DNA和蛋白质代谢的影响。数据显示，接触尼古丁后，成年肺中的抗坏血酸含量降低了76%。相比之下，怀孕和哺乳期间母体尼古丁暴露对新生儿肺抗坏血酸含量没有影响。然而，怀孕和哺乳期间补充抗坏血酸可预防母体尼古丁暴露对新生儿肺碳水化合物、DNA和蛋白质代谢的不利影响。