Sepulveda R L, Ferrer X, Latrach C, Sorensen R U
Immunology Section, National Institute of Respiratory Diseases and Thoracic Surgery, New Orleans, Louisiana.
Am Rev Respir Dis. 1990 Jul;142(1):24-8. doi: 10.1164/ajrccm/142.1.24.
The booster or enhancement effect of repeated tuberculin skin testing in Calmette-Guérin bacillus (BCG)-vaccinated young adults was studied in 208 first-year medical, nursing, and medical technology students in Santiago, Chile, where BCG vaccine is usually administered at birth and at 6 and 14 yr of age. Thirty-three students had no BCG scar, 62 had one scar, 71 had two scars, and 42 had three scars. The mean age for each group was 19 yr. All students were healthy and had no known exposure to tuberculosis or history of tuberculosis or other mycobacterioses. The size in millimeters of induration of the first tuberculin reaction (PPD1) was clearly correlated with the number of BCG scars: 2.3 +/- 4.6 for no scars; 6.7 +/- 6.7 for one scar; 10.9 +/- 5.9 for two scars, and 13.2 +/- 5.3 for three scars. The second tuberculin reaction (PPD2), performed 2 wk later on the contralateral forearm, showed a marked increase in reactivity. The increase in reaction size was most evident in students who had BCG scars but who were initially PPD negative (less than 10 mm). Smaller increases were observed in students without BCG scars, and also in those who had BCG scars but who were initially tuberculin positive (greater than or equal to 10 mm). The persistence of the booster effect was evaluated by performing PPD3 1 yr later. PPD1-negative students with BCG scars maintained the increased level of reactivity to PPD2 after 1 yr. An immunizing effect of tuberculin testing was suggested in 11 nonimmunized students who were initially PPD negative.(ABSTRACT TRUNCATED AT 250 WORDS)
在智利圣地亚哥，对208名一年级医学、护理和医学技术专业学生进行了研究，以探讨在接种卡介苗（BCG）的年轻成年人中重复结核菌素皮肤试验的增强或强化效果。在当地，BCG疫苗通常在出生时、6岁和14岁时接种。33名学生没有BCG疤痕，62名有一处疤痕，71名有两处疤痕，42名有三处疤痕。每组的平均年龄为19岁。所有学生均健康，无已知结核暴露史、结核病史或其他分枝杆菌病病史。首次结核菌素反应（PPD1）硬结的毫米大小与BCG疤痕数量明显相关：无疤痕者为2.3±4.6；一处疤痕者为6.7±6.7；两处疤痕者为10.9±5.9；三处疤痕者为13.2±5.3。2周后在对侧前臂进行的第二次结核菌素反应（PPD2）显示反应性显著增加。反应大小的增加在有BCG疤痕但最初PPD阴性（小于10毫米）的学生中最为明显。在没有BCG疤痕的学生以及有BCG疤痕但最初结核菌素阳性（大于或等于10毫米）的学生中观察到较小的增加。通过1年后进行PPD3评估增强效应的持续性。有BCG疤痕的PPD1阴性学生在1年后维持了对PPD2的反应性增加水平。在11名最初PPD阴性的未免疫学生中提示了结核菌素试验的免疫效果。（摘要截短于250字）
