Eriksen N H, Hartzen S H, Bangsborg J, Andersen L P, Rosdahl V T, Espersen F
Staphylococcus Laboratory, Statens Seruminstitut, Copenhagen, Denmark.
Epidemiol Infect. 1994 Feb;112(1):81-92. doi: 10.1017/s0950268800057447.
During the period 1961-91 a total of 567,635 strains of Staphylococcus aureus from hospitalized patients in Denmark have been characterized according to their antibiotic resistance, site of isolation and phage type. Strains of phage group II (typed by the phages 3A, 3C, 55 and 71) have been analysed further. The occurrence of group II strains was relatively constant (approximately 16%) from 1961 until 1983. Since then the frequency of group II strains increased; in 1991 they accounted for 22.7% of all S. aureus strains isolated. Strains of group II can, on the basis of their phage types, be divided in four subgroups: 3A, 71, 71+ and the 'rest of group II'. Furthermore, within these groups strains may differ from one another in respect to their sensitivity to phages. The increased isolation of group II strains during recent years was because of an increase in strains of subgroups 71+ and the 'rest of group II strains'. In 1991 these two subgroups accounted for 89.7% of all group II strains. Furthermore, an increasing number of group II strains, 71.4% in 1991, was typable only at RTD x 100. The increase in the number of group II strains was even throughout Denmark. All four subgroups of group II have, during the observation period, become more frequently resistant to penicillin and/or tetracycline. Strains typed at 100 x RTD of subgroup 71+ and the 'rest of group II' are more frequently antibiotic resistant than the rest of the group II strains. Strains of the increasing subgroups occurred most often in abscesses.
在1961年至1991年期间，丹麦对住院患者分离出的总共567,635株金黄色葡萄球菌进行了抗生素耐药性、分离部位和噬菌体分型特征分析。对II组噬菌体（由噬菌体3A、3C、55和71分型）的菌株进行了进一步分析。1961年至1983年期间，II组菌株的出现率相对稳定（约16%）。从那时起，II组菌株的频率增加；1991年，它们占所有分离出的金黄色葡萄球菌菌株的22.7%。II组菌株可根据其噬菌体分型分为四个亚组：3A、71、71+和“II组其他菌株”。此外，在这些组内，菌株对噬菌体的敏感性可能彼此不同。近年来II组菌株分离增加是由于71+亚组和“II组其他菌株”数量增加。1991年，这两个亚组占所有II组菌株的89.7%。此外，越来越多的II组菌株（1991年为71.4%）仅在RTD×100时可分型。II组菌株数量的增加在丹麦各地是均匀的。在观察期内，II组的所有四个亚组对青霉素和/或四环素的耐药性都变得更加频繁。71+亚组和“II组其他菌株”在100×RTD分型的菌株比II组其他菌株更频繁地具有抗生素耐药性。增加的亚组菌株最常出现在脓肿中。
