Mild haemophilia A fails to protect from coronary artery disease: the report of two cases.

The description of two additional cases of coronary artery disease in haemophiliacs is reported. Both patients are affected by mild haemophilia A. The first one was not aware of his coagulation disorder and therefore he had never been treated with FVIII concentrates, despite the occurrence of severe and recurrent articular and gastric bleeding episodes. He underwent cardiac catheterization that gave evidence of extensive coronary atherosclerosis. Percutaneous transluminal coronary angioplasty (PTCA) was then performed. The second patient had an inferior myocardial infarction. Influence of cardiovascular risk factors in haemophiliacs and the possible role of thrombosis in the pathogenesis of atherosclerosis are discussed.