Baughn R E
Med Microbiol Immunol. 1975 Sep 19;161(4):243-52. doi: 10.1007/BF02122712.
Normal mice and mice displaying delayed hypersensitivity to Staphylococcus aureus were challenged with a lethal dose of Listeria monocytogenes. Nonspecific antimicrobial activity was assessed by inhibition of bacterial growth in the spleen and by increased survival rates. Administration of specific staphylococcal antigen prior to challenge was a prerequisite for the induction of nonspecific resistance. Both the time of administering eliciting antigen and the route were important consideration for evoking the response. Similar responses were seen in 3 strains of inbred mice following immunization with both encapsulated and nonencapsulated staphylococci. Although enhanced resistance as measured by viable counts in the spleens was achieved after 2 injections, protection as measured by survival required 4 injections of S. aureus followed by elicitation with staphylococcal antigens. Nonspecific resistance could be detected as late as 9 weeks after the disappearance of delayed hypersensitivity.
用致死剂量的单核细胞增生李斯特菌攻击正常小鼠和对金黄色葡萄球菌表现出迟发型超敏反应的小鼠。通过抑制脾脏中的细菌生长和提高存活率来评估非特异性抗菌活性。在攻击前给予特异性葡萄球菌抗原是诱导非特异性抗性的先决条件。给予引发抗原的时间和途径都是引发反应的重要考虑因素。在用包膜和非包膜葡萄球菌免疫后，3个近交系小鼠品系出现了类似的反应。尽管通过脾脏活菌计数测量的抗性增强在2次注射后实现，但通过存活率测量的保护需要4次注射金黄色葡萄球菌，随后用葡萄球菌抗原进行激发。在迟发型超敏反应消失后长达9周仍可检测到非特异性抗性。
