Kowalski J J, Berman D T
Infect Immun. 1971 Sep;4(3):205-11. doi: 10.1128/iai.4.3.205-211.1971.
Guinea pigs sensitized with washed, Formalin-killed cells of Staphylococcus aureus, strains 263 or Copenhagen, were skin-tested with various antigens from these strains including washed viable and heat-killed whole cells, cell walls, the peptidoglycan complexes of the walls, teichoic acid, teichoic acid-peptidoglycan fragments, and peptidoglycan fragments. In nonsensitized control animals, all antigens but teichoic acid elicited acute inflammatory reactions which decreased in size after 10 hr. In animals sensitized with the Copenhagen strain, the reactions to all antigens but teichoic acid and peptidoglycan fragments from either strain remained erythematous and indurated for at least 30 hr and were interpreted as hypersensitivity of the delayed type. Responses in animals sensitized with strain 263 generally resembled those in controls, although in some experiments there was evidence of hypersensitivity.
用金黄色葡萄球菌263株或哥本哈根株经洗涤并用福尔马林灭活的细胞致敏的豚鼠，用来自这些菌株的各种抗原进行皮肤试验，这些抗原包括洗涤后的活的和热灭活的全细胞、细胞壁、细胞壁的肽聚糖复合物、磷壁酸、磷壁酸 - 肽聚糖片段以及肽聚糖片段。在未致敏的对照动物中，除磷壁酸外的所有抗原均引发急性炎症反应，10小时后反应大小减小。在用哥本哈根菌株致敏的动物中，除磷壁酸和来自任一菌株的肽聚糖片段外，对所有抗原的反应至少30小时保持红斑和硬结，并被解释为迟发型超敏反应。用263株致敏的动物的反应通常与对照动物相似，尽管在一些实验中有超敏反应的证据。
