Wildfeuer M E
Tippecanoe Laboratories, Eli Lilly and Company, Lafayette, Indiana.
J Antibiot (Tokyo). 1994 Jan;47(1):64-71. doi: 10.7164/antibiotics.47.64.
Acetylation of desacetyl glutaryl 7-aminocephalosporanic acid (7ACA), an intermediate in the two-stage enzymatic cleavage of cephalosporin C, has been accomplished in aqueous media with acetic anhydride. Because the reaction is done in water, conversion of desacetyl glutaryl 7ACA to glutaryl 7ACA can be accomplished at an early stage in the purification process. Evidence is presented that desacetyl cephalosporin C in cephalosporin C broth is formed from the mycelial catalyzed hydrolysis of cephalosporin C.
去乙酰基戊二酰-7-氨基头孢烷酸（7ACA）是头孢菌素C两步酶促裂解过程中的一种中间体，其乙酰化反应已在水介质中用乙酸酐完成。由于该反应在水中进行，因此去乙酰基戊二酰-7ACA向戊二酰-7ACA的转化可在纯化过程的早期阶段实现。有证据表明，头孢菌素C发酵液中的去乙酰基头孢菌素C是由头孢菌素C的菌丝体催化水解形成的。
