豚鼠投射至肠系膜下神经节的肠感觉纤维在结肠扩张后的活动

Activity following colonic distension in enteric sensory fibres projecting to the inferior mesenteric ganglion in the guinea pig.

作者信息

Bywater R A

机构信息

Department of Physiology, Monash University, Clayton, Victoria, Australia.

出版信息

J Auton Nerv Syst. 1994 Jan-Feb;46(1-2):19-26. doi: 10.1016/0165-1838(94)90140-6.

DOI:10.1016/0165-1838(94)90140-6

PMID:8120340

Abstract

In this investigation the characteristics of the response to colonic distension of afferent fibres projecting to the inferior mesenteric ganglion (IMG) of the guinea pig were studied in vitro. Intracellular membrane potential recordings were made from neurons in the IMG. Post-synaptic potentials arising from activity in afferent fibres were recorded in these cells following distensions of a small segment of colon placed in a separate and independently perfused organ bath. These afferent fibres showed both transient and sustained responses to distension. Application of a solution containing 0.25 mM Ca2+ and 10 mM2+ Mg2+ to the colon (but not to the IMG) reduced the overall response but did not abolish the activity in these fibres. It is concluded that some afferent fibres which respond to colonic distension project directly to the IMG.

摘要

在本研究中，在体外研究了投射到豚鼠肠系膜下神经节（IMG）的传入纤维对结肠扩张反应的特征。从IMG中的神经元进行细胞内膜电位记录。在置于单独且独立灌注的器官浴中的一小段结肠扩张后，在这些细胞中记录由传入纤维活动产生的突触后电位。这些传入纤维对扩张表现出短暂和持续的反应。向结肠（而非IMG）施加含有0.25 mM Ca2+和10 mM Mg2+的溶液可降低总体反应，但并未消除这些纤维中的活动。得出的结论是，一些对结肠扩张有反应的传入纤维直接投射到IMG。