Housley E, Leng G C, Donnan P T, Fowkes F G
Department of Medicine, Royal Infirmary of Edinburgh.
J Epidemiol Community Health. 1993 Dec;47(6):475-80. doi: 10.1136/jech.47.6.475.
To determine associations between physical activity at age 35-45 years with peripheral arterial disease and cardiovascular risk factors at age 55-74 years.
Cross sectional survey of the general population--Edinburgh Artery Study. The presence of peripheral arterial disease was determined using the WHO/Rose questionnaire on intermittent claudication, and the ankle brachial pressure index at rest and during reactive hyperaemia. Levels of physical activity undertaken at the time of the survey and at the times the subjects were aged 35-45 years were measured by self administered recall questionnaire.
City of Edinburgh, Scotland.
Altogether 1592 men and women aged 55 to 74 years, selected from the age-sex registers of 10 general practices spread geographically and socioeconomically throughout the city.
Participation in moderate or strenuous activity when aged 35-45 years was reported by 66% of men and 40% of women. In men, but not in women, less peripheral arterial disease (measured by an increasing trend in the ankle brachial pressure index) was found with increasing amounts of exercise at age 35-45 years (p < 0.001). Higher levels of exercise at age 35-45 years were associated with lower blood viscosity (p < 0.05) and plasma fibrinogen levels (p < 0.05) in men and women aged 55-74 years, and also with higher current alcohol intake (p < 0.001) and high density lipoprotein cholesterol concentrations (p < 0.01) in women aged 55-74 years. After adjustment for age, sex, life-time smoking, social class, body mass index, and alcohol intake, the association between leisure activity aged 35-45 years and the ankle brachial pressure index aged 55-74 years remained highly significant in men who had at some time smoked (p < 0.001) but not in men or women who had never smoked (p > 0.05).
The risk of peripheral arterial disease, particularly among male smokers, is inversely related to previous physical activity in early middle age, suggesting a protective effect of exercise.
确定35至45岁时的身体活动与55至74岁时的外周动脉疾病及心血管危险因素之间的关联。
对普通人群进行横断面调查——爱丁堡动脉研究。使用世界卫生组织/罗斯关于间歇性跛行的问卷以及静息和反应性充血期间的踝臂压力指数来确定外周动脉疾病的存在情况。通过自我回忆问卷测量调查时以及受试者35至45岁时所进行的身体活动水平。
苏格兰爱丁堡市。
从全市10家全科诊所的年龄-性别登记册中选取的1592名年龄在55至74岁之间的男性和女性，这些诊所分布在地理和社会经济层面上具有多样性。
据报告，66%的男性和40%的女性在35至45岁时参与了中度或剧烈活动。在男性中，但在女性中未发现，35至45岁时运动量增加与外周动脉疾病减少（通过踝臂压力指数上升趋势衡量）相关（p<0.001）。35至45岁时较高的运动水平与55至74岁男性和女性较低的血液粘度（p<0.05）和血浆纤维蛋白原水平（p<0.05）相关，也与55至74岁女性较高的当前酒精摄入量（p<0.001）和高密度脂蛋白胆固醇浓度（p<0.01）相关。在对年龄、性别、终生吸烟情况、社会阶层、体重指数和酒精摄入量进行调整后，35至45岁时的休闲活动与55至74岁时的踝臂压力指数之间的关联在曾经吸烟的男性中仍然高度显著（p<0.001），但在从未吸烟的男性或女性中不显著（p>0.05）。
外周动脉疾病的风险，尤其是在男性吸烟者中，与中年早期以前的身体活动呈负相关，表明运动具有保护作用。
