Nduele M, Ludwig A, Van Ooteghem M
University of Antwerp (UIA), Dept. Pharmaceutical Sciences, Wilrijk.
J Pharm Belg. 1993 Sep-Oct;48(5):325-34.
Cassava, corn and potato starch were, after storage at various conditions of temperature and relative humidity, mixed with a model drug phenacetin. The powder mixtures were filled into hard gelatin capsules. The powder beds containing 20% and 50% starch do not disintegrate within 2 hours. The shortest disintegration time was observed for the mixture containing 80% potato starch. The dissolution rate of phenacetin depends on the porosity of the powder bed filled and the kind of starch used. Potato starch improves the availability of the drug. The disintegration action of corn and cassava starch are almost identical.
木薯淀粉、玉米淀粉和马铃薯淀粉在不同温度和相对湿度条件下储存后，与模型药物非那西丁混合。将粉末混合物填充到硬明胶胶囊中。含有20%和50%淀粉的粉末床在2小时内不会崩解。含80%马铃薯淀粉的混合物崩解时间最短。非那西丁的溶解速率取决于填充粉末床的孔隙率和所用淀粉的种类。马铃薯淀粉可提高药物的可利用性。玉米淀粉和木薯淀粉的崩解作用几乎相同。
