Nakaya Y, Katayama T, Nomura M, Ishimura Y, Ohuchi T, Oka M, Yamamoto M, Mizobuchi S
Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
Am Heart J. 1994 Mar;127(3):613-7. doi: 10.1016/0002-8703(94)90671-8.
sulfoconjugated dopamine constitutes the major portion of circulating or excreted dopamine, but its physiologic significance is still unknown. To test whether conjugated dopamine serves as a source of free dopamine in response to acute stress, plasma concentrations of free and conjugated dopamine were measured during an acute exacerbation of heart failure. The plasma concentration of conjugated dopamine decreased significantly during the acute phase of heart failure, whereas that of free dopamine increased. The plasma concentration of free dopamine decreased, whereas the concentration of conjugated dopamine increased as heart failure improved. An infusion of dopamine increased the plasma concentration of conjugated dopamine, suggesting that at least part of the excess active dopamine was detoxified through conjugation. The results of these tests with both conjugated and free dopamine are interconvertible and indicate that conjugated dopamine can serve as a reservoir of active dopamine.
硫酸化多巴胺是循环或排泄多巴胺的主要成分，但其生理意义仍不清楚。为了测试结合型多巴胺是否作为急性应激时游离多巴胺的来源，在心力衰竭急性加重期间测量了游离和结合型多巴胺的血浆浓度。心力衰竭急性期结合型多巴胺的血浆浓度显著降低，而游离多巴胺的血浆浓度升高。随着心力衰竭改善，游离多巴胺的血浆浓度降低，而结合型多巴胺的浓度升高。多巴胺输注增加了结合型多巴胺的血浆浓度，表明至少部分过量的活性多巴胺通过结合作用被解毒。这些关于结合型和游离型多巴胺的测试结果是可相互转换的，表明结合型多巴胺可作为活性多巴胺的储备库。
