Larnier C, Ortonne J P, Venot A, Faivre B, Béani J C, Thomas P, Brown T C, Sendagorta E
Produits Roche, Neuilly, France.
Br J Dermatol. 1994 Feb;130(2):167-73. doi: 10.1111/j.1365-2133.1994.tb02895.x.
Clinical assessments of photodamage are based upon a subjective evaluation of characteristic features such as wrinkling and pigmentary change, and are influenced by inter-observer differences in grading criteria. In an effort to standardize the grading of photodamage severity, we have developed a six-point photographic scale in which each of the six grades of overall photodamage severity is depicted by three photographs. The use of three photographs to portray each grade illustrates the diversity and range of manifestations within each grade. This photographic scale was tested by two groups of dermatologists, who used it on two occasions to grade the overall photodamage severity of a single group of female Caucasian subjects. Results indicate high inter-observer agreement, with chance-corrected agreement ranging from 0.44 to 0.63 and from 0.54 to 0.76 on the first and second occasions, respectively. Intra-observer repeatability was high, with chance-corrected agreement ranging from 0.56 to 0.78. Inter- and intra-observer differences were within one category in nearly all cases. Similar grades were assigned by dermatologists with and without experience in treating photodamaged patients. We conclude that application of this scale results in consistent and reproducible clinical evaluations of overall photodamage severity in Caucasian subjects. The scale may be useful in categorizing subjects for epidemiological studies, or in selecting patients for clinical trials.
光损伤的临床评估基于对诸如皱纹和色素变化等特征的主观评价,并且受观察者间分级标准差异的影响。为了使光损伤严重程度的分级标准化,我们制定了一个六点摄影量表,其中光损伤总体严重程度的六个等级中的每一个等级都由三张照片描绘。用三张照片来描述每个等级说明了每个等级内表现的多样性和范围。两组皮肤科医生对这个摄影量表进行了测试,他们分两次使用该量表对一组白人女性受试者的光损伤总体严重程度进行分级。结果表明观察者间的一致性很高,第一次和第二次观察时,校正机遇后的一致性分别为0.44至0.63和0.54至0.76。观察者内的可重复性很高,校正机遇后的一致性为0.56至0.78。几乎在所有情况下,观察者间和观察者内的差异都在一个等级范围内。有和没有治疗光损伤患者经验的皮肤科医生给出了相似的等级。我们得出结论,应用这个量表可以对白人受试者的光损伤总体严重程度进行一致且可重复的临床评估。该量表可能有助于对流行病学研究的受试者进行分类,或为临床试验选择患者。