Ohm M J, Galask R P
Am J Obstet Gynecol. 1975 Nov 15;123(6):590-6. doi: 10.1016/0002-9378(75)90880-7.
A prospective, double-blind study was conducted to evaluate the effect of cephalosporins on morbidity in women undergoing vaginal hysterectomy. Each patient received a five-day course of an active drug or a placebo beginning the night before operation. Microbiological studies, including culture and antibiotic sensitivities, were done on each patient pre- and post-operatively. Of 23 women who received the placebo, 11 (48 percent) were classified as morbid. They had either an operative bed infection or a urinary tract infection. Only a small number of cephalosporin-resistant organisms were involved in these infections. Of the 25 women who received the cephalosporins, none (0 per cent) was classified as morbid. A small increase in the number of cephalosporin-resistant organisms (most notably Pseudomonas aeruginosa) was found postoperatively. Four patients were readmitted with pelvic infections after their original discharge. Microbiological data and a discussion of these infections are presented.
进行了一项前瞻性双盲研究，以评估头孢菌素对接受阴道子宫切除术女性发病率的影响。每位患者在手术前一晚开始接受为期五天的活性药物或安慰剂治疗。对每位患者在术前和术后进行了微生物学研究，包括培养和抗生素敏感性测试。在接受安慰剂的23名女性中，11名（48%）被归类为发病。她们要么发生了手术部位感染，要么发生了尿路感染。这些感染中仅涉及少数对头孢菌素耐药的微生物。在接受头孢菌素的25名女性中，无一人（0%）被归类为发病。术后发现对头孢菌素耐药的微生物数量略有增加（最显著的是铜绿假单胞菌）。四名患者在最初出院后因盆腔感染再次入院。文中呈现了微生物学数据以及对这些感染的讨论。
