Parker D C
Department of Molecular Genetics, University of Massachusetts Medical School, Worcester 01655.
Semin Immunol. 1993 Dec;5(6):413-20. doi: 10.1006/smim.1993.1047.
B cells get help from T cells by acting as antigen-specific APC. A signal from the B cell antigen receptor is not required for efficient antigen presentation or for the B cell response to T cell help. T cells provide help by making lymphokines, some of which, like CD40 ligand, remain T cell-associated and require cell contact for function. The function of class II MHC is to induce help in the T cell, rather than to deliver help to the B cell. T cell help uses different intracellular signaling pathways from those engaged by the B cell antigen receptor.
B细胞通过作为抗原特异性抗原呈递细胞（APC）获得T细胞的帮助。有效的抗原呈递或B细胞对T细胞帮助的反应并不需要来自B细胞抗原受体的信号。T细胞通过产生淋巴因子来提供帮助，其中一些淋巴因子，如CD40配体，仍与T细胞相关联，并且其功能需要细胞接触。II类主要组织相容性复合体（MHC）的功能是在T细胞中诱导帮助，而不是向B细胞提供帮助。T细胞帮助所使用的细胞内信号通路与B细胞抗原受体所涉及的不同。
