Sathananthan A H
Trobe University and Monash Medical Centre, Melbourne, Australia.
Microsc Res Tech. 1994 Feb 1;27(2):145-64. doi: 10.1002/jemt.1070270208.
This paper reviews the process of peri-ovulatory oocyte maturation and the ultrastructural organization of the human egg and compares it with that of the mouse. The main thrust of the paper is on the human, since there are several reviews on the mouse. Both preovulatory and postovulatory events at fertilization, as well as some of the aberrant features of maturation are covered. Some changes induced by oocyte culture and cooling in the human are also included. The report attempts to focus on unique features of the human oocyte and shows a variety of ultrastructural differences between human and murine oocytes, which may well reflect differences in their physiology and biochemistry. Based on these differences and further observations on the process of fertilization of both species, particularly with respect to the inheritance of paternal centrioles, it is concluded that the mouse may not be a suitable model for the development and refinement of current procedures in human assisted reproductive technology.
本文回顾了排卵前后卵母细胞成熟的过程以及人类卵子的超微结构组织，并将其与小鼠的进行了比较。由于已有多篇关于小鼠的综述，本文的重点在于人类。文中涵盖了受精时排卵前和排卵后的事件，以及成熟过程中的一些异常特征。还包括了人类卵母细胞培养和冷却所引起的一些变化。该报告试图聚焦于人类卵母细胞的独特特征，并展示了人类和小鼠卵母细胞之间的多种超微结构差异，这很可能反映了它们在生理和生化方面的差异。基于这些差异以及对两个物种受精过程的进一步观察，特别是关于父本中心粒的遗传，得出结论：小鼠可能不是人类辅助生殖技术中当前程序开发和完善的合适模型。
