Le Loët X, De Bandt M, Lioté F, Daragon A, Kahn M F, Mejjad O
Service de Rhumatologie, CHU, Rouen.
Rev Rhum Ed Fr. 1993 Jun;60(6):416-9.
The interactions between pregnancy and adult-onset Still's disease are unclear. Nine pregnancies which occurred from 1983 through 1991 in seven women (mean age 27.7 years; range 23-40) were studied retrospectively. Five patients had one pregnancy and two had two pregnancies. Onset of the joint disease occurred before or during pregnancy. The joint disease occurred at the 5th or 6th month of the first pregnancy in two patients; one of these patients had a second pregnancy which was not associated with a flare. In five patients, onset of the joint disease occurred 4, 15, 42, 44 and 58 months before the first pregnancy, respectively; any effects of the joint disease on the pregnancy were extremely variable. 6 infants were full-term and two were premature (35 weeks); the remaining pregnancy was electively terminated; Apgar scores were normal in all eight infants, who were all male. Adult-onset Still's disease did not influence the outcome of the pregnancy in our patients; no clear-cut effects of pregnancy on adult-onset Still's disease were seen.
妊娠与成人斯蒂尔病之间的相互作用尚不清楚。我们对1983年至1991年间7名女性（平均年龄27.7岁；范围23 - 40岁）发生的9次妊娠进行了回顾性研究。5名患者有1次妊娠，2名患者有2次妊娠。关节疾病在妊娠前或妊娠期间发作。两名患者的关节疾病在首次妊娠的第5或6个月发作；其中一名患者再次妊娠，未出现病情复发。在5名患者中，关节疾病分别在首次妊娠前4、15、42、44和58个月发作；关节疾病对妊娠的任何影响差异极大。6名婴儿足月出生，2名早产（35周）；其余妊娠为选择性终止妊娠；所有8名婴儿（均为男性）的阿氏评分均正常。成人斯蒂尔病未影响我们患者的妊娠结局；未观察到妊娠对成人斯蒂尔病有明确影响。
