Shinpo K, Fukazawa T, Hamada T, Moriwaka F, Tashiro K
Department of Neurology, Hokkaido University School of Medicine.
Rinsho Shinkeigaku. 1993 Nov;33(11):1175-8.
A 32-year-old man with chronic alcoholism over 10 years developed skin eruptions, dark-red tongue and severe watery diarrhea, followed by weakness of bilateral lower extremities. Physical examination revealed hyperpigmented skin eruptions with scales on the dorsa of his hands and extensor aspects of his forearms. Neurological examination showed proximal muscle weakness of both lower extremities, hyperactive knee and ankle jerks, positive Chaddock reflexes and stocking type sensory disturbances. Laboratory data revealed elevation of myolytic enzyme, hypokalemia and decrease of niacin level in the blood. Diagnosis of hypokalemic myopathy and pellagra was made. With the correction of serum potassium level, muscle weakness improved rapidly and with the supplement of niacin, other physical signs and symptoms improved. In this case hypokalemic myopathy could be attributed to the alcoholic malnutritional state such as pellagrous diarrhea, malnutrition, malabsorption and others.
一名32岁、有超过10年慢性酒精中毒史的男性出现皮肤疹、暗红色舌头及严重水样腹泻,随后双下肢无力。体格检查发现其双手背部及前臂伸侧有色素沉着性皮疹并伴有鳞屑。神经学检查显示双下肢近端肌无力、膝跳反射和踝反射亢进、查多克征阳性及袜套型感觉障碍。实验室检查数据显示肌溶解酶升高、低钾血症及血液中烟酸水平降低。诊断为低钾性肌病和糙皮病。随着血清钾水平的纠正,肌无力迅速改善,补充烟酸后,其他体征和症状也有所改善。在该病例中,低钾性肌病可归因于酒精性营养不良状态,如糙皮性腹泻、营养不良、吸收不良等。