Inohara S, Kitano Y, Sagami S
Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan.
Int J Dermatol. 1993 Dec;32(12):866-9. doi: 10.1111/j.1365-4362.1993.tb01400.x.
Ras p21, a ras oncogene product, plays an important role in tumorigenesis, proliferation, and differentiation in various tissues and cells.
Using a monoclonal antibody raised against ras p21 (RASK 4), localization of ras p21 in normal epidermis and involved epidermis of various skin diseases was examined immunohistologically.
Ras p21 was not present in basal cells of normal epidermis or basaloid cells of basal cell epithelioma but was found almost evenly in the cytoplasm of squamous cells and granular cells. This suggests that ras p21 is concerned with differentiation of epidermal cells. The mode of distribution of ras p21 differed from one cell to another in epidermal cells that turned to malignancy. The distribution was uneven and irregular in the tumorous region on the whole.
This result might possibly represent abnormal differentiation of epidermal cells that turned to malignancy, deviating from the regular mode of the distribution of ras p21, which is necessary for normal differentiation.
Ras p21是一种Ras癌基因产物，在各种组织和细胞的肿瘤发生、增殖及分化过程中发挥重要作用。
使用针对Ras p21制备的单克隆抗体（RASK 4），通过免疫组织化学方法检测Ras p21在正常表皮及各种皮肤疾病受累表皮中的定位。
Ras p21在正常表皮的基底细胞或基底细胞上皮瘤的基底样细胞中不存在，但在鳞状细胞和颗粒细胞的细胞质中几乎均匀分布。这表明Ras p21与表皮细胞的分化有关。在恶变的表皮细胞中，Ras p21的分布模式因细胞而异。总体而言，肿瘤区域的分布不均匀且不规则。
这一结果可能代表了恶变的表皮细胞的异常分化，偏离了正常分化所必需的Ras p21的正常分布模式。
