Conrad B, Kriebel J, Hetzel W D
J Neurol. 1978 Aug 25;218(4):263-74. doi: 10.1007/BF00312882.
A new genetic syndrome of the combined occurrence of hypogonadotropic hypogonadism, anosmia (Kallmann syndrome) and congenital mirror movements in four brothers is presented. Mirror movements were manifest only within the distal parts of the upper extremities and resembled congenital mirror movements described for isolated or familial cases or those occurring in combination with other genetic defects. The hypothesis is supported, that a midline fusion disorder with preponderance of uncrossed pyramidal tract fibers is a major pathogenetic factor for the occurrence of congenital mirror movements.
本文报告了一个新的遗传综合征，该综合征表现为四名兄弟同时出现低促性腺激素性性腺功能减退、嗅觉缺失（卡尔曼综合征）和先天性镜像运动。镜像运动仅在上肢远端出现，类似于孤立或家族性病例中描述的先天性镜像运动，或与其他遗传缺陷合并出现的镜像运动。有观点认为，以未交叉的锥体束纤维占优势的中线融合障碍是先天性镜像运动发生的主要致病因素，这一假说得到了支持。
