Hausken T, Berstad A
Medical Dept. A, University of Bergen, Norway.
Scand J Gastroenterol. 1994 Jan;29(1):23-8. doi: 10.3109/00365529409090432.
Nitric oxide (NO) is considered to be an important physiologic non-adrenergic, non-cholinergic vagal transmitter in the neural regulation of gastric adaptive relaxation, which accommodates the gastric fundus to ingested food. Ten consecutive patients with functional dyspepsia (FD) and erosive prepyloric changes were studied twice on separate days, once without drug administration and once after intake of one tablet of glyceryl trinitrate (GTN), 2.6 mg, 2 h before ingestion of 500 ml meat soup. Width of antral area, amplitude (maximal area reduction as fraction of relaxed area), and frequency of antral contractions were measured ultrasonographically in standardized sections. Postprandial abdominal discomfort was scored. Without GTN, postprandial antral area and symptom scores were positively correlated (r = 0.64, p = 0.05). After administration of GTN, antral area both fasting and 10 min postprandially was reduced (p = 0.02 and p = 0.01, respectively), whereas amplitude and motility index of antral contractions tended to increase (p = 0.07 and p = 0.09, respectively). Abdominal discomfort was not significantly reduced by GTN (p = 0.13). The results suggest a relationship between postprandial antral distension and discomfort. Moreover, GTN (by generation of NO) reduced abnormal antral filling in patients with FD.
一氧化氮（NO）被认为是胃适应性舒张神经调节中一种重要的生理性非肾上腺素能、非胆碱能迷走神经递质，胃适应性舒张可使胃底容纳摄入的食物。对10例连续性功能性消化不良（FD）且有幽门前糜烂改变的患者在不同日期进行了两次研究，一次在未给药时，另一次在摄入500 ml肉汤前2小时服用一片2.6 mg硝酸甘油（GTN）后。在标准化切片中用超声测量胃窦区宽度、幅度（最大面积减少量占舒张面积的比例）和胃窦收缩频率。对餐后腹部不适进行评分。未服用GTN时，餐后胃窦区面积与症状评分呈正相关（r = 0.64，p = 0.05）。服用GTN后，空腹及餐后10分钟时胃窦区面积均减小（分别为p = 0.02和p = 0.01），而胃窦收缩的幅度和动力指数有增加趋势（分别为p = 0.07和p = 0.09）。GTN并未显著减轻腹部不适（p = 0.13）。结果提示餐后胃窦扩张与不适之间存在关联。此外，GTN（通过生成NO）减少了FD患者胃窦的异常充盈。
