Lin X, Levanon D, Chen J D
Lynn Institute for Healthcare Research, Oklahoma City, Oklahoma 73112, USA.
Dig Dis Sci. 1998 Aug;43(8):1678-84. doi: 10.1023/a:1018806913907.
The aim of this study was to investigate gastric myoelectrical activity in patients with functional dyspepsia. Thirteen healthy subjects and 14 patients with functional dyspepsia participated in the study. The electrogastrogram (EGG) recording was made in each subject for 30 min in the fasting state and 120 min after a standard test meal of 475 calories. Spectral analysis methods were applied to derive quantitative EGG parameters. There was no difference in the EGG between the patients and controls in the fasting state. However, abnormalities in the postprandial EGG were found in the patients. The percentage of 2-4 cpm waves was significantly lower (74.4+/-4.0% vs 85.7+/-1.6%, P < 0.03) and the postprandial increase in EGG dominant power was significantly less (-0.52+/-0.92 dB vs 2.24+/-0.88 dB, P < 0.03) in patients than in controls. It was also found that the percentage of postprandial 2-4 cpm waves could be used to differentiate the patients with functional dyspepsia from the healthy controls with a specificity of 100% and a sensitivity of 43%. It was concluded that a subset of patients with functional dyspepsia have impaired gastric myoelectrical activity in the fed state.
本研究的目的是调查功能性消化不良患者的胃肌电活动。13名健康受试者和14名功能性消化不良患者参与了该研究。在空腹状态下，对每个受试者进行30分钟的胃电图（EGG）记录，并在进食475卡路里的标准试验餐后120分钟进行记录。应用频谱分析方法得出定量的EGG参数。在空腹状态下，患者与对照组的EGG无差异。然而，在患者中发现了餐后EGG异常。患者餐后2 - 4次/分钟波的百分比显著降低（74.4±4.0%对85.7±1.6%，P < 0.03），且患者餐后EGG主导功率的增加显著低于对照组（-0.52±0.92 dB对2.24±0.88 dB，P < 0.03）。还发现餐后2 - 4次/分钟波的百分比可用于区分功能性消化不良患者与健康对照组，特异性为100%，敏感性为43%。得出的结论是，一部分功能性消化不良患者在进食状态下胃肌电活动受损。
