Stoll T, Brühlmann P, Fontana A, Gmür J, Michel B A
Rheumaklinik, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1994 Feb 5;124(5):193-203.
Systemic sclerosis is a rare chronic disease with inflammatory and vascular features leading to increased fibrosis of skin and internal organs. The pathogenesis of systemic sclerosis and scleroderma like diseases appears to be influenced rather by environmental than by genetic factors. Clinical and pathogenetic aspects of systemic sclerosis show similarities to untreated chronic graft-versus-host-disease after bone marrow transplantation. New insights into the pathogenesis of systemic sclerosis give reason to hope that better therapeutic approaches will be developed in the future.
系统性硬化症是一种罕见的慢性疾病，具有炎症和血管特征，可导致皮肤和内脏器官纤维化加剧。系统性硬化症及硬皮病样疾病的发病机制似乎更多地受环境因素而非遗传因素影响。系统性硬化症的临床和发病机制方面与骨髓移植后未经治疗的慢性移植物抗宿主病相似。对系统性硬化症发病机制的新见解让人们有理由希望未来能开发出更好的治疗方法。
