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The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy.

作者信息

Leonard W J

机构信息

Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

出版信息

Curr Opin Immunol. 1994 Aug;6(4):631-5. doi: 10.1016/0952-7915(94)90152-x.

DOI:10.1016/0952-7915(94)90152-x
PMID:7946053
Abstract

The interleukin-2 receptor plays a pivotal role in the regulation of the normal T cell immune response to foreign antigen. The IL-2 receptor gamma-chain is one component of this receptor, and is encoded by the gene that is defective in X-linked severe combined immunodeficiency. The clinical manifestations of this disease led to the hypothesis and subsequent confirmation that the gamma-chain was in fact a subunit shared by multiple cytokine receptors, including those for IL-2, IL-4, and IL-7.

摘要

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1
The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy.
Curr Opin Immunol. 1994 Aug;6(4):631-5. doi: 10.1016/0952-7915(94)90152-x.
2
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Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.白细胞介素-2受体γ链在白细胞介素-7受体复合物中的功能参与。
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Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.人类白细胞介素-7受体复合物中的共享γ(c)亚基。X连锁重症联合免疫缺陷病发病机制的分子基础。
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