Pyke S D, Thompson S G, Buchwalsky R, Kienast J
Medical Statistics Unit, London School of Hygiene and Tropical Medicine, United Kingdom.
Thromb Haemost. 1993 Nov 15;70(5):743-6.
The variability of haemostatic factor measurements in patients presenting with angina pectoris is investigated. In all, 219 middle aged patients (almost all men) provided repeat measurements 2.5 years apart on a battery of haemostatic and haematological tests and other cardiovascular risk factors. Correlations between repeat measurements were lower than might be expected in a healthy population, reflecting a relatively large degree of variability within individuals over time. The highest correlations observed for haemostatic factors were for von Willebrand factor related antigen (r = 0.48) and fibrinogen (r = 0.45). The correlations were generally lower amongst patients who had undergone coronary surgery or angioplasty between the two measurements. We conclude that the underlying relationship of fibrinogen to coronary risk must be much greater than is generally appreciated, since even single measurements are found to be important predictors of risk, despite only moderate stability over time. The very low correlations for beta-thromboglobulin (r = 0.10) and platelet factor 4 (r = 0.03) which were observed in this study casts doubt on their potential usefulness as predictors of long-term cardiovascular risk.
对患有心绞痛的患者止血因子测量的变异性进行了研究。共有219名中年患者（几乎全是男性）对一系列止血和血液学检测以及其他心血管危险因素进行了两次间隔2.5年的重复测量。重复测量之间的相关性低于健康人群的预期，这反映出个体随时间存在相对较大程度的变异性。观察到的止血因子之间最高的相关性是血管性血友病因子相关抗原（r = 0.48）和纤维蛋白原（r = 0.45）。在两次测量之间接受过冠状动脉手术或血管成形术的患者中，相关性通常较低。我们得出结论，纤维蛋白原与冠状动脉风险的潜在关系肯定比一般认为的要大得多，因为即使单次测量也被发现是风险的重要预测指标，尽管随时间的稳定性仅为中等。在本研究中观察到的β-血小板球蛋白（r = 0.10）和血小板因子4（r = 0.03）的极低相关性，让人怀疑它们作为长期心血管风险预测指标的潜在有用性。
