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颈动脉体瘤的诊断与治疗

Diagnosis and treatment of carotid body tumors.

作者信息

Rabl H, Friehs I, Gutschi S, Pascher O, Koch G

机构信息

Department of Vascular Surgery, University of Graz, Austria.

出版信息

Thorac Cardiovasc Surg. 1993 Dec;41(6):340-3. doi: 10.1055/s-2007-1013886.

DOI:10.1055/s-2007-1013886
PMID:8128461
Abstract

Carotid body tumors are rare although they must always remain part of the differential diagnosis of a neck mass. Sonography as the screening method of choice followed by angiography determines the diagnosis. In 11 patients 12 carotid body tumors were extirpated. The reconstruction of the internal carotid artery with an interposition of the greater saphenous vein was necessary in two cases after resection of the tumor. One patient underwent preoperative embolisation because of a huge tumor. Two postoperative radiotherapies were undertaken because of malignancy in one case and a partially extirpated tumor in the other. After a 9 year follow-up period all patients are alive. One patient suffers from a persistent palsy of the hypoglossal nerve and another complains of permanent headache supposedly caused by the reocclusion of the venous interposition of the carotid artery. In conclusion, our data support the diagnostic strategies in patients with suspected carotid body tumors. Regarding the exact therapeutic regimen, we suggest the surgical resection, followed by radiotherapy in cases of confirmed malignancy or partially resectable lesions.

摘要

颈动脉体瘤虽然罕见,但在颈部肿块的鉴别诊断中始终应将其纳入考虑范围。超声作为首选的筛查方法,随后进行血管造影以明确诊断。11例患者共切除12个颈动脉体瘤。2例患者在肿瘤切除后需要用大隐静脉移植重建颈内动脉。1例患者因肿瘤巨大接受了术前栓塞。1例患者因肿瘤恶性,另1例因肿瘤部分切除后进行了2次术后放疗。经过9年的随访,所有患者均存活。1例患者出现舌下神经持续性麻痹,另1例患者抱怨持续头痛,推测是由于颈动脉静脉移植再闭塞所致。总之,我们的数据支持对疑似颈动脉体瘤患者的诊断策略。关于确切的治疗方案,我们建议手术切除,对于确诊为恶性或部分可切除病变的患者,术后进行放疗。

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1
Diagnosis and treatment of carotid body tumors.颈动脉体瘤的诊断与治疗
Thorac Cardiovasc Surg. 1993 Dec;41(6):340-3. doi: 10.1055/s-2007-1013886.
2
Management of carotid body tumors and familial paragangliomas: review of 30 years' experience.颈动脉体瘤和家族性副神经节瘤的管理:30年经验回顾
Ann Vasc Surg. 2009 Sep-Oct;23(5):616-20. doi: 10.1016/j.avsg.2009.06.014.
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A multidisciplinary approach to carotid paragangliomas.颈动脉体瘤的多学科治疗方法。
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Carotid body tumors: challenging complexity of diagnosis and surgical treatment.颈动脉体瘤:诊断与手术治疗面临的复杂挑战
Kulak Burun Bogaz Ihtis Derg. 2003 Jan;10(1):8-12.
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[Carotid body tumor].[颈动脉体瘤]
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[Glomus tumors: a diagnostic and surgical challenge?].[血管球瘤:诊断与手术挑战?]
Z Kardiol. 1994 May;83(5):373-80.
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Surgical treatment of paragangliomas of the carotid bifurcation: results of 36 patients.颈动脉分叉处副神经节瘤的手术治疗:36例患者的结果
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Clinical and pathological analysis of malignant carotid body tumour: a report of nine cases.恶性颈动脉体瘤的临床与病理分析:附9例报告
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引用本文的文献

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Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets.颈动脉体与代谢综合征:机制与潜在治疗靶点。
Int J Mol Sci. 2020 Jul 20;21(14):5117. doi: 10.3390/ijms21145117.
2
Diagnosis and surgical treatment of carotid body tumor: A retrospective analysis of 58 patients.颈动脉体瘤的诊断与外科治疗:58例患者的回顾性分析
Oncol Lett. 2017 Sep;14(3):3628-3632. doi: 10.3892/ol.2017.6582. Epub 2017 Jul 15.
3
Carotid body paragangliomas: a systematic study on management with surgery and radiotherapy.颈动脉体副神经节瘤:手术和放疗治疗的系统研究。
Eur Arch Otorhinolaryngol. 2014 Jan;271(1):23-34. doi: 10.1007/s00405-013-2384-5. Epub 2013 Feb 19.
4
Diagnosis and treatment of carotid body paraganglioma: 21 years of experience at a clinical center of Serbia.颈动脉体副神经节瘤的诊断与治疗:塞尔维亚一家临床中心21年的经验
World J Surg Oncol. 2005 Feb 12;3(1):10. doi: 10.1186/1477-7819-3-10.