Severson J A, Marcusson J, Winblad B, Finch C E
J Neurochem. 1982 Dec;39(6):1623-31. doi: 10.1111/j.1471-4159.1982.tb07996.x.
Human caudate nucleus, putamen, substantia nigra, and nucleus accumbens were analyzed for the effects of age on dopaminergic binding sites. Decreases in the number of dopaminergic binding sites were detected with age in caudate nucleus (44 specimens from three sample groups) and substantia nigra (n = 12). In caudate nucleus, the decline in [3H]2-amino-6, 7-dehydroxy-1, 2, 3, 4-tetrahydronaphthalene sites was three times greater than for [3H]spiperone, but age changes were significant in only two of the three sampling groups. No age changes in binding were detected in the putamen (n = 44) or nucleus accumbens. Age, sex, and tissue source all significantly contributed to variance. However, cause of death, time from death to tissue freezing, and length of storage did not influence dopaminergic binding in the caudate nucleus or putamen. Relative to the life-span, the age-correlated decrease in dopaminergic binding sites of human brain approximates that in aging rodent striatum. Comparisons of altered dopaminergic binding with other age-correlated changes suggest that neuronal loss may not be involved in the loss of binding sites before midlife.
分析了人类尾状核、壳核、黑质和伏隔核中年龄对多巴胺能结合位点的影响。在尾状核（来自三个样本组的44个标本）和黑质（n = 12）中，随着年龄增长检测到多巴胺能结合位点数量减少。在尾状核中，[3H]2-氨基-6,7-二羟基-1,2,3,4-四氢萘位点的下降幅度是[3H]螺哌隆的三倍，但在三个采样组中只有两个组的年龄变化具有显著性。在壳核（n = 44）或伏隔核中未检测到结合的年龄变化。年龄、性别和组织来源均对变异有显著影响。然而，死亡原因、从死亡到组织冷冻的时间以及储存时间均不影响尾状核或壳核中的多巴胺能结合。相对于寿命而言，人类大脑中与年龄相关的多巴胺能结合位点减少情况与衰老啮齿动物纹状体中的情况相近。将多巴胺能结合改变与其他与年龄相关的变化进行比较表明，中年之前结合位点的丧失可能与神经元丢失无关。
