Scott I U, Schein O D, West S, Bandeen-Roche K, Enger C, Folstein M F
Wilmer Ophthalmological Institute, Baltimore, MD.
Arch Ophthalmol. 1994 Mar;112(3):329-35. doi: 10.1001/archopht.1994.01090150059023.
Assessment of the relationship between visual function and functional status/quality of life in clinical research involving patients with eye disease by investigating whether the scores of four existing functional status/quality of life patient questionnaires are sensitive to differences in visual acuity and studying whether selected subscales of the questionnaires provide similar information concerning the relationship between functional status/quality of life and visual acuity as do the respective full-length questionnaires.
DESIGN, SETTING, PARTICIPANTS: Case patients consisted of 86 consecutive patients seen at The Wilmer Ophthalmological Institute Retinal Vascular Center, Baltimore, Md. Controls consisted of 51 individuals with normal visual acuity and no known ocular disease and were frequency-matched to the case patients by age (+/- 5 years), sex, and race. Subjects were interviewed in person using each of the following questionnaires: the Sickness Impact Profile, the vision-specific Sickness Impact Profile, the Community Disability Scale, and the General Health Questionnaire.
Scores of all four questionnaires and their subscales were significantly associated with visual acuity. The vision-specific Sickness Impact Profile and the Community Disability Scale were independently significant predictors of visual acuity. Regression analysis revealed that in our study, selected subscales of the respective full-length questionnaires were able to demonstrate the association between vision and functional status/quality of life.
Ophthalmic patients are at high risk for decreased functional status/quality of life. Subscales of existing questionnaires potentially may be substituted for the full-length questionnaires, thereby increasing the efficiency of functional status/quality of life measurement in such patients.
通过研究四份现有的患者功能状态/生活质量问卷的得分对视力差异是否敏感，以及研究问卷中选定的子量表是否能像相应的完整问卷那样提供有关功能状态/生活质量与视力之间关系的类似信息，来评估在涉及眼病患者的临床研究中视觉功能与功能状态/生活质量之间的关系。
设计、地点、参与者：病例患者包括在马里兰州巴尔的摩市威尔默眼科研究所视网膜血管中心连续就诊的86名患者。对照组由51名视力正常且无已知眼病的个体组成，按年龄（±5岁）、性别和种族与病例患者进行频率匹配。使用以下问卷对受试者进行个人访谈：疾病影响量表、视力特异性疾病影响量表、社区残疾量表和一般健康问卷。
所有四份问卷及其子量表的得分均与视力显著相关。视力特异性疾病影响量表和社区残疾量表是视力的独立显著预测因素。回归分析显示，在我们的研究中，相应完整问卷的选定子量表能够证明视力与功能状态/生活质量之间的关联。
眼科患者功能状态/生活质量下降的风险很高。现有问卷的子量表可能可以替代完整问卷，从而提高此类患者功能状态/生活质量测量的效率。
