Coskuncan N M, Jabs D A, Dunn J P, Haller J A, Green W R, Vogelsang G B, Santos G W
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.
Arch Ophthalmol. 1994 Mar;112(3):372-9. doi: 10.1001/archopht.1994.01090150102031.
To evaluate the posterior segment ocular complications of patients undergoing bone marrow transplantation (BMT).
Retrospective analysis.
Academic ophthalmology department at a tertiary care hospital with a BMT unit.
Patients undergoing BMT were seen by an ophthalmologist for clinical care and enrolled in a long-term follow-up study, during which they were seen 6 and 12 months after the transplantation and annually thereafter.
Of 397 patients undergoing BMT, 51 (12.8%) developed posterior segment complications. Fourteen patients (3.5%) developed hemorrhagic complications with either intraretinal and/or vitreous hemorrhages and 17 patients (4.3%) developed cotton-wool spots in the fundus of both eyes. Eleven patients (2.8%) had bilateral optic disc edema, with eight cases attributed to the toxic effects of cyclosporine and three to other causes. Two patients (0.5%) developed serious retinal detachments. Eight patients (2.0%) developed infectious retinitis and/or endophthalmitis. Fungal infections with Candida or Aspergillus usually occurred within 120 days after BMT, while viral infections with herpes zoster or cytomegalovirus and parasitic infections with Toxoplasma occurred later. Intraocular lymphoma occurred in one patient (0.2%).
Severe, potentially vision-threatening, posterior segment complications following BMT occur due to a variety of causes.
评估接受骨髓移植（BMT）患者的眼后段并发症。
回顾性分析。
一家设有BMT单元的三级医疗医院的学术眼科部门。
接受BMT的患者由眼科医生进行临床诊治，并纳入一项长期随访研究，在此期间，他们在移植后6个月和12个月接受检查，此后每年检查一次。
在397例接受BMT的患者中，51例（12.8%）出现眼后段并发症。14例患者（3.5%）出现出血性并发症，表现为视网膜内和/或玻璃体积血，17例患者（4.3%）双眼眼底出现棉絮斑。11例患者（2.8%）出现双侧视盘水肿，其中8例归因于环孢素的毒性作用，3例归因于其他原因。2例患者（0.5%）发生严重视网膜脱离。8例患者（2.0%）发生感染性视网膜炎和/或眼内炎。念珠菌或曲霉菌真菌感染通常发生在BMT后120天内，而带状疱疹或巨细胞病毒病毒感染以及弓形虫寄生虫感染则发生较晚。1例患者（0.2%）发生眼内淋巴瘤。
BMT后发生的严重、可能威胁视力的眼后段并发症由多种原因引起。
