Harris G J, Murphy M L, Schmidt E W, Hanson G A, Dotson R M
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee.
Arch Ophthalmol. 1994 Mar;112(3):380-6. doi: 10.1001/archopht.1994.01090150110032.
We describe a patient with bilateral orbital myositis, multiple cranial neuropathies, a sensory polyneuropathy, serum and cerebrospinal fluid paraproteins, and high-grade non-Hodgkin's lymphoma. Neurologic symptoms began more than 1 year before diagnosis of the lymphoma. Results of extraocular muscle biopsy showed extensive destruction of myofibers and granulomatous features, with no evidence of direct tumor involvement. The cranial neuropathies and orbital myositis improved with immunosuppressive therapy, while the patient's tumor progressed. We believe the orbital myositis and the multiple neurologic abnormalities were paraneoplastic effects of the lymphoma. To our knowledge, this is the first case of orbital myositis identified as a paraneoplastic syndrome.
我们描述了一名患有双侧眼眶肌炎、多发性颅神经病变、感觉性多发性神经病、血清和脑脊液副蛋白以及高级别非霍奇金淋巴瘤的患者。神经症状在淋巴瘤诊断前1年多就已出现。眼外肌活检结果显示肌纤维广泛破坏并有肉芽肿特征，无直接肿瘤累及的证据。免疫抑制治疗后颅神经病变和眼眶肌炎有所改善，但患者的肿瘤仍在进展。我们认为眼眶肌炎和多种神经异常是淋巴瘤的副肿瘤效应。据我们所知，这是首例被确定为副肿瘤综合征的眼眶肌炎病例。
