系统性硬化症中的抗组蛋白抗体。与肺纤维化的关联。
Antihistone antibodies in systemic sclerosis. Association with pulmonary fibrosis.
作者信息
Sato S, Ihn H, Kikuchi K, Takehara K
机构信息
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
出版信息
Arthritis Rheum. 1994 Mar;37(3):391-4. doi: 10.1002/art.1780370313.
OBJECTIVE
To determine the prevalence and clinical significance of antihistone antibodies (AHA) in systemic sclerosis (SSc).
METHODS
Serum samples from patients with limited cutaneous SSc (n = 44), diffuse cutaneous SSc (dcSSc; n = 48), and other SSc-related disorders (n = 22) were examined by enzyme-linked immunosorbent assay and immunoblotting for AHA.
RESULTS
AHA were demonstrated in 29% of the 92 SSc patients and in 44% of those with dcSSc. The presence of AHA correlated with severe pulmonary fibrosis in those with dcSSc. Immunoblotting revealed that the predominant antigen was histone H1.
CONCLUSION
AHA might be a serologic indicator of the severity of pulmonary fibrosis in SSc.
目的
确定抗组蛋白抗体（AHA）在系统性硬化症（SSc）中的患病率及临床意义。
方法
采用酶联免疫吸附测定法和免疫印迹法检测局限性皮肤型SSc患者（n = 44）、弥漫性皮肤型SSc（dcSSc；n = 48）及其他SSc相关疾病患者（n = 22）的血清样本中的AHA。
结果
92例SSc患者中有29%检测出AHA，dcSSc患者中有44%检测出AHA。dcSSc患者中AHA的存在与严重肺纤维化相关。免疫印迹显示主要抗原为组蛋白H1。
结论
AHA可能是SSc中肺纤维化严重程度的血清学指标。
Zotero 插件