Department of Dermatology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Clin Rheumatol. 2013 Jan;32(1):43-7. doi: 10.1007/s10067-012-2089-y. Epub 2012 Sep 16.
Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen-related superfamily of proteins, is expressed on the surface of macrophages, T cells, and endothelial cells and directly cleaves prothrombin to thrombin. The aim of this study is to determine the serum FGL2 level and its association with clinical parameters in patients with systemic sclerosis (SSc). Serum FGL2 level was examined by enzyme-linked immunosorbent assay in 61 patients with SSc, 24 patients with systemic lupus erythematosus, and 24 healthy individuals. In a retrospective longitudinal study, sera from 13 patients with SSc were analyzed. The serum FGL2 level was increased in patients with SSc compared with healthy individuals (P < 0.001) and patients with systemic lupus erythematosus (P < 0.01). Among patients with SSc, there were no differences in serum FGL2 level between limited cutaneous SSc and diffuse cutaneous SSc. In the longitudinal study, the FGL2 level was generally unchanged at follow-up. The results show that the serum FGL2 level was increased in patients with SSc but not in patients with systemic lupus erythematosus or healthy individuals. Therefore, FGL2 possibly contribute to the development of SSc.
纤维蛋白原样蛋白 2（FGL2）是纤维蛋白原相关蛋白超家族的成员之一，表达于巨噬细胞、T 细胞和内皮细胞表面，并可直接将凝血酶原裂解为凝血酶。本研究旨在检测系统性硬化症（SSc）患者血清 FGL2 水平及其与临床参数的相关性。采用酶联免疫吸附试验检测 61 例 SSc 患者、24 例系统性红斑狼疮患者和 24 例健康对照者的血清 FGL2 水平。对 13 例 SSc 患者进行回顾性纵向研究，分析其血清学指标。与健康对照者（P<0.001）和系统性红斑狼疮患者（P<0.01）相比，SSc 患者血清 FGL2 水平升高。在 SSc 患者中，局限性和弥漫性皮肤型 SSc 患者的血清 FGL2 水平无差异。在纵向研究中，随访时 FGL2 水平总体无变化。结果表明，SSc 患者的血清 FGL2 水平升高，而系统性红斑狼疮患者或健康对照者的 FGL2 水平无变化。因此，FGL2 可能参与了 SSc 的发病。
