Recanatini E, Marcheggiani F, Corinaldesi G, Gazzanelli G, Saccucci F, Possati L
Istituto di Scienze Biomediche, Università di Ancona.
Boll Soc Ital Biol Sper. 1993 Feb;69(2):129-35.
Two human cellular lines of cancerous small lung cells obtained from biopsies specimens from two patients were characterized in vitro according to cellular morphology, growth modality, caryotype and antigenic profile. In vivo studies were carried out by inoculating the cells into nude mice of both sexes and various ages by different routes in order to study tumorigenicity and metastatic capacity and to identify a biological marker of the malignancy. Results obtained to date suggest that the two cellular lines have different biological properties similar to the classic and the variant form found in literature. A biological marker of the malignancy seems to be the antigenic profile of the cells.
从两名患者的活检标本中获取的两个人类小肺癌细胞系，根据细胞形态、生长方式、核型和抗原谱在体外进行了特征描述。通过将细胞以不同途径接种到不同年龄和性别的裸鼠体内进行体内研究，以研究致瘤性和转移能力，并确定恶性肿瘤的生物学标志物。迄今为止获得的结果表明，这两个细胞系具有不同的生物学特性，类似于文献中发现的经典形式和变异形式。恶性肿瘤的生物学标志物似乎是细胞的抗原谱。
