Goren A, Glaser J, Drukker A
Division of Paediatric Cardiology, Shaare Zedek Medical Centre, Hebrew University Medical School, Jerusalem, Israel.
Pediatr Nephrol. 1993 Dec;7(6):725-8. doi: 10.1007/BF01213334.
Thirty-seven children and adolescents on renal replacement therapy (11 on haemodialysis, 14 on continuous ambulatory peritoneal dialysis and 12 after renal transplantation) were studied by echocardiography, echo-Doppler and phonocardiography. Right and left ventricular (R/L V) diastolic functions were measured by transmitral and transtricuspid flow velocities and by LV isovolumic relaxation time (LVIRT). Thirty-seven age- and sex-matched healthy subjects served as controls. R/L V diastolic dysfunction was only observed in the dialysis patients. In these patients LVIRT was prolonged. LV and RV peak inflow velocities were increased both in early (E) and late (A) diastole with a reduction in the E/A ratios. This pattern of diastolic dysfunction is compatible with the combined effects of a hypercirculatory state (volume overload, anaemia, arteriovenous fistula) and an abnormality of cardiac relaxation. The transplant patients showed no major cardiac abnormalities.
对37名接受肾脏替代治疗的儿童和青少年（11名接受血液透析，14名接受持续性非卧床腹膜透析，12名接受肾移植）进行了超声心动图、超声多普勒和心音图检查。通过二尖瓣和三尖瓣血流速度以及左心室等容舒张时间（LVIRT）来测量右心室和左心室（R/L V）舒张功能。37名年龄和性别匹配的健康受试者作为对照。仅在透析患者中观察到R/L V舒张功能障碍。在这些患者中，LVIRT延长。左心室和右心室舒张早期（E）和晚期（A）的峰值血流速度均增加，E/A比值降低。这种舒张功能障碍模式与高循环状态（容量超负荷、贫血、动静脉瘘）和心脏舒张异常的综合作用相符。移植患者未表现出重大心脏异常。
