Lessells A M, Beck J S, Burnett R A, Howatson S R, Lee F D, McLaren K M, Moss S M, Robertson A J, Simpson J G, Smith G D
Department of Pathology, Western General Hospital, Edinburgh, Scotland.
J Clin Pathol. 1994 Jan;47(1):48-52. doi: 10.1136/jcp.47.1.48.
To study the consistency of reporting of abnormal rectal biopsy specimens, especially in the differentiation of inflammatory bowel disease from other causes of abnormality.
Sixty rectal biopsy specimens were identified from patients presenting with bloody diarrhoea. These were then circulated to the 11 consultant pathologists in the study who filled in a proforma with a list of 12 diagnostic categories and 22 features.
Forty one of the 60 cases were examples of inflammatory bowel disease. In 33 of these cases nine or more pathologists had made the diagnosis. Further categorisation into ulcerative colitis and Crohn's disease showed better recognition of ulcerative colitis. In the 19 cases of non-inflammatory bowel disease recognition of pseudomembranous colitis and solitary rectal ulcer syndrome was good, but the results were poorer in the case of infective colitis.
The findings suggest that a group of consultant pathologists can differentiate between inflammatory bowel disease and other causes of an abnormal rectal biopsy specimen and can also recognise pseudomembranous colitis and solitary rectal ulcer syndrome satisfactorily.
研究直肠活检标本异常报告的一致性，尤其是在区分炎症性肠病与其他异常原因方面。
从出现血性腹泻的患者中识别出60份直肠活检标本。然后将这些标本分发给该研究中的11位顾问病理学家，他们填写了一份包含12个诊断类别和22项特征的表格。
60例病例中有41例为炎症性肠病。在其中33例病例中，有9名或更多病理学家做出了诊断。进一步分类为溃疡性结肠炎和克罗恩病显示对溃疡性结肠炎的识别更好。在19例非炎症性肠病病例中，对伪膜性结肠炎和孤立性直肠溃疡综合征的识别较好，但感染性结肠炎的结果较差。
研究结果表明，一组顾问病理学家能够区分炎症性肠病与直肠活检标本异常的其他原因，并且也能令人满意地识别伪膜性结肠炎和孤立性直肠溃疡综合征。
