电子显微镜检查在肾脏疾病诊断中的价值。
Value of electron microscopy in diagnosis of renal disease.
作者信息
Pearson J M, McWilliam L J, Coyne J D, Curry A
机构信息
Department of Pathological Sciences, University Hospital of South Manchester, Withington Hospital, Didsbury.
出版信息
J Clin Pathol. 1994 Feb;47(2):126-8. doi: 10.1136/jcp.47.2.126.
AIMS
To assess the role and value of electron microscopy in the diagnosis of renal disease.
METHODS
Retrospective evaluation of 88 renal biopsy specimens received for primary diagnosis by assessment of the contribution of electron microscopy to the final diagnosis in the knowledge of the light microscopy and immunofluorescence findings.
RESULTS
Electron microscopy had an important diagnostic role in 75% of cases and was essential or necessary for diagnosis in 25%. In 25% of cases electron microscopy was considered unhelpful in diagnosis.
CONCLUSION
Electron microscopy has an integral role in the diagnosis of renal disease, and tissue should be taken for electron microscopy in all cases if possible. In some selected cases once the light microscopy and immunofluorescence findings are known it may be possible to forego electron microscopic examination. Electron microscopy is particularly useful in the differential diagnosis of minimal change disease and the nephrotic syndrome.
目的
评估电子显微镜在肾脏疾病诊断中的作用和价值。
方法
回顾性评估88例接受初步诊断的肾活检标本，在已知光镜和免疫荧光检查结果的情况下，评估电子显微镜对最终诊断的贡献。
结果
电子显微镜在75%的病例中具有重要诊断作用，在25%的病例中对诊断至关重要或必不可少。在25%的病例中，电子显微镜被认为对诊断无帮助。
结论
电子显微镜在肾脏疾病诊断中具有不可或缺的作用，如有可能，所有病例均应取组织进行电子显微镜检查。在某些特定病例中，一旦已知光镜和免疫荧光检查结果，可能无需进行电子显微镜检查。电子显微镜在微小病变病和肾病综合征的鉴别诊断中特别有用。
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