Erika M, Anna K, Péter B, Ferenc L, Harry J
Morphol Igazsagugyi Orv Sz. 1976 Jan;16(1):9-22.
Investigation of kidney-biopsy taken from 17 children was carried out. The techniques used were: light-microscopic investigation of paraffin sections and ultrathin sections, electron microscopic investigation of the latter and basal-membrane measurements. According to the author's opinion electron microscopic investigation of kidney-biopsy is reasonable only in selected cases, representing special clinical and therapeutic problems. In cases of nephrosis syndrome electron microscopy helps in differentiation of the "mimimal lesion" and the early phase of the focal sclerotizing glomerular lesion. Further it gives good results in observation of mono- and olygosystemic diseases of the kidney. In the author's material electron microscopy contributed to more differentiated morphological diagnosis in 2/3 rds of the cases investigated. The authors join to the opinion of other investigators stressing that light-microscopical investigation should be completed by the light-microscopy of uktrathin scretions even then, when there are no possibilities of electonmicroscopical study.
对17名儿童的肾活检组织进行了研究。采用的技术包括：石蜡切片和超薄切片的光学显微镜检查、后者的电子显微镜检查以及基底膜测量。作者认为，仅在某些特定病例中，对肾活检组织进行电子显微镜检查才是合理的，这些病例代表了特殊的临床和治疗问题。在肾病综合征病例中，电子显微镜有助于区分“微小病变”和局灶性节段性肾小球硬化病变的早期阶段。此外，它在观察肾脏的单系统和多系统疾病方面也能取得良好效果。在作者的研究材料中，电子显微镜在三分之二的研究病例中有助于做出更具鉴别性的形态学诊断。作者赞同其他研究者的观点，强调即使在没有电子显微镜研究条件的情况下，光学显微镜检查也应由超薄切片的光学显微镜检查来补充。
