Martin G, Forte P, Luchsinger A, Mendoza F, Urbina-Quintana A, Hernandez Pieretti O, Romero E, Velasco M
Clinical Pharmacology Unit, Vargas Medical School, Caracas, Venezuela.
J Clin Pharmacol. 1994 Jan;34(1):91-4. doi: 10.1002/j.1552-4604.1994.tb03971.x.
Eleven patients with moderate to severe hypertension were studied at the Vargas Hospital of Caracas. The patients were pretreated with labetalol, 800 to 1200 mg/day, orally, over a period of 1 week, after which an intravenous infusion of dopamine, .5 to 3 micrograms/kg/minute, was given. Two intravenous dopamine infusions (30 minutes each) were performed before and after the injection of metoclopramide (30 mg, intravenous bolus). Two washout periods were also included before and after metoclopramide administration. Dopamine induced a decrease of blood pressure from 171.9 + 6.35/103.6 +/- 3.12 to 152.7 +/- 7.55/93.8 +/- 2.97 mm Hg (P < .001) without altering heart rate, and it increased plasma insulin levels from 8.29 +/- .70 microU/mL to 12.09 +/- 1.83 microU/mL (P < .01). Metoclopramide caused no changes of blood pressure or plasma insulin levels. Hypotensive responses and plasma insulin increases due to dopamine were blocked by metoclopramide, however. The authors conclude that a dopaminergic receptor may be involved in some cardiovascular responses and in modulating insulin secretion in humans.
在加拉加斯的瓦尔加斯医院对11名中重度高血压患者进行了研究。患者先口服拉贝洛尔，800至1200毫克/天，持续1周，之后静脉输注多巴胺，剂量为0.5至3微克/千克/分钟。在注射甲氧氯普胺（30毫克，静脉推注）前后分别进行两次静脉多巴胺输注（每次30分钟）。在甲氧氯普胺给药前后还包括两个洗脱期。多巴胺使血压从171.9±6.35/103.6±3.12毫米汞柱降至152.7±7.55/93.8±2.97毫米汞柱（P<.001），且未改变心率，同时使血浆胰岛素水平从8.29±0.70微单位/毫升升至12.09±1.83微单位/毫升（P<.01）。甲氧氯普胺未引起血压或血浆胰岛素水平的变化。然而，甲氧氯普胺阻断了多巴胺引起的降压反应和血浆胰岛素升高。作者得出结论，多巴胺能受体可能参与了人体的一些心血管反应以及调节胰岛素分泌。
