Fiszer U, Mix E, Fredrikson S, Kostulas V, Olsson T, Link H
Department of Neurology, Karolinska Institute, Huddinge Hospital, Sweden.
J Neurol Sci. 1994 Jan;121(1):39-45. doi: 10.1016/0022-510x(94)90154-6.
The etiology of Parkinson's disease is mainly unknown. Immune abnormalities have been reported, including the occurrence of autoantibodies against neuronal structures and abnormal T cell functions. gamma delta+ T cells represent a recently recognized T cell subpopulation which is considered to play a role in immune responses in infections and autoimmunity. We examined by three-colour flow cytometry the proportions of gamma delta+ T cells in blood and cerebrospinal fluid (CSF) from patients with Parkinson's disease. Increased proportions of gamma delta+ T cells were found in CSF in Parkinson's disease compared to other neurological diseases (OND) and tension headache. In peripheral blood, patients with Parkinson's disease had higher numbers of gamma delta+ T cells compared to OND patients. No differences between gamma delta+ T cells in CSF compared to blood were demonstrable in the individual patient groups. CD25 was not expressed on gamma delta+ T cells in blood of the majority of cases, but 50% of patients with Parkinson's disease and 30% with OND and tension headache had CD25+ gamma delta+ T cells in CSF arguing for a preferential activation of gamma delta+ T cells in the CSF compartment. Whether the elevated gamma delta+ T cell population in Parkinson's disease reflects previously unrecognized inflammation or may occur also in non-inflammatory disorders remains to be elucidated.
帕金森病的病因主要不明。已有免疫异常的报道，包括出现针对神经元结构的自身抗体以及T细胞功能异常。γδ+ T细胞是最近才被认识的T细胞亚群，被认为在感染和自身免疫的免疫反应中起作用。我们通过三色流式细胞术检测了帕金森病患者血液和脑脊液（CSF）中γδ+ T细胞的比例。与其他神经系统疾病（OND）和紧张性头痛相比，帕金森病患者脑脊液中γδ+ T细胞的比例增加。在周围血液中，帕金森病患者的γδ+ T细胞数量高于OND患者。在各个患者组中，脑脊液中的γδ+ T细胞与血液中的γδ+ T细胞之间未显示出差异。大多数病例血液中的γδ+ T细胞不表达CD25，但50%的帕金森病患者、30%的OND患者和紧张性头痛患者脑脊液中有CD25+γδ+ T细胞，这表明脑脊液中的γδ+ T细胞优先被激活。帕金森病中γδ+ T细胞数量增加是反映了以前未被认识的炎症，还是也可能发生在非炎症性疾病中，仍有待阐明。
